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Epidemiological studies have shown that prenatal infection combined with trauma exposure during prepuberty significantly increases SCZ risk compared to either factor alone, especially in boys (Debost et al., 2017)

Endocrinology 149 , 39093919 (2008)

p = 0.04) [13]

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The nature of the cholinergic hypothesis is based on the suppressed synthesis of the neurotransmitter acetylcholine and therefore the therapeutic intervention is based on the restoration of the physiological level of acetylcholine by inhibiting the activity of enzyme acetylcholinesterase (AChE) (Bartus et al