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Abbreviations AD: Alzheimers disease APOE: Apolipoprotein E ASC: Apoptosis-associated speck-like protein containing a CARD BDNF: Brain-derived neurotrophic factor CASP1: Caspase 1 CLEC7A: C-type lectin domain containing 7A CTCF: Corrected total cell fluorescence DAM: Disease-associated microglia DAMP: Damage-associated molecular pattern EV: Extracellular vesicle GSDMD: Gasdermin D GSH: Glutathione GSHee: Glutathione ethyl ester LDH: Lactate dehydrogenase LPS: Lipopolysaccharide MGnD: Microglial neurodegenerative MSU: Monosodium urate crystals MDP: Muramyl dipeptide NGF: Nerve growth factor NT3/4: Neurotrophin 3/4 NLRP1/3: NLR family pyrin domain containing 1/3 PAMP: Pathogen-associated molecular pattern References Abbott A

BPC-157 works through multiple interconnected signaling cascades rather than binding to a single identified receptor