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Exercise and Physical Performance Research Age-Related Physical Decline Investigations in aging mice demonstrated that MOTS-c treatment significantly improved physical capacity across multiple age groups: Enhanced running endurance in young (2-month), middle-aged (12-month), and old (22-month) mice Improved grip strength and rotarod performance in aged animals Late-life intermittent treatment (beginning at 23.5 months) increased healthspan metrics Reversal of age-dependent decline in mitochondrial function Notably, human studies confirmed that exercise induces endogenous MOTS-c expression in both skeletal muscle tissue and circulation, suggesting evolutionary conservation of exercise-responsive signaling

doi: 10.1016/j.jff.2025.106981 40

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doi: 10.1016/j.tibs.2013.01.004 67 JiangZ.LinJ.DongH.ZhengX.MarjaniS