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In 2022, Lu et al

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Consequently, a phase 3 trial on ambroxol has been planned and is due to start recruitment in the near future (NCT05778617), a phase 2 trial in GBA-associated PD is ongoing (NCT05287503) [124], and another phase 2 trial on PD dementia is expected to finish in December 2025 (NCT02914366) [125]

Mild ferroptosis is proposed to impair repair (190), but it is unknown whether there is a threshold of ferroptosis that switches repair from adaptive to maladaptive, or which molecular signals govern this switch