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Similarly, the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial demonstrated a significant reduction in cardiovascular events in individuals with overweight or obesity, with subsequent analysis addressing prespecified kidney endpoints

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Indeed, GCG antagonists, developed as potential glucose-lowering therapies, were associated with an increase in hepatic steatosis [38], suggesting that GCG agonists may reduce hepatic steatosis [39]