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separate if possible Proton pump inhibitors : Long-term use may reduce magnesium absorption (MHRA Drug Safety Update), potentially increasing supplementation needs Diuretics : Particularly loop and thiazide diuretics can increase urinary magnesium losses Always consult the British National Formulary (BNF) or individual medication SmPCs for specific separation timing recommendations

Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing appetite Acting on central nervous system pathways involved in appetite regulation These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight reduction in those with obesity

The medication works by slowing gastric emptying, which means food stays in your stomach longer, helping you feel satisfied with smaller portions

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