52: 1730 [DOI] [PubMed] [Google Scholar]
GLP-1 binds to GLP-1 receptor (GLP-1R), a G-coupled receptor readily found in pancreatic cells, intestine and central nervous system and moderately expressed in blood vessels, pancreatic alpha cells, peripheral nervous system, lungs, heart, kidneys and joints [7]
Data mining of the public version of the FDA Adverse Event Reporting System
Tirzepatide and retatrutide, which have dual agonist activities targeting both GLP-1 receptor and GIP receptor (GIPR) or GLP-1 receptor and glucagon receptor (GCGR), respectively, have been shown to improve energy expenditure and metabolic flexibility in other studies [50, 51]
10.1042/bj0010028 90 MllerT