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Reduced fat cushioning = Less shock absorption: Fat around joints, especially the l ower back and hips, does more than store energy

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At baseline, the mean AHI was 51.5 in trial 1 and 49.5 in trial 2

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The use of nalbuphine, a blocker of - and -opioid receptors, also disrupted the effect of GLP-1RAs on reducing TNF- levels, highlighting the essential role of these opioid receptors in the anti-inflammatory effects mediated by GLP-1RAs