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Bacterial release is accompanied by ectopic accumulation of cell wall material around the vacuole in nodules of Pisum sativum sym33-3 allele encoding transcription factor PsCYCLOPS/PsIPD3

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Additionally, ROS-induced oxidative modifications of cellular macromolecules generate damage-associated molecular patterns (DAMPs), which are recognized by pattern recognition receptors, such as Toll-like receptors (TLRs), thereby perpetuating sterile inflammatory responses (Koenig and Buskiewicz-Koenig, 2022)

About 40% of participants lost 25% or more