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In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average

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The use of probiotics (such as Bifidobacteria) or prebiotics (such as fructooligosaccharides) can improve the composition of the gut microbiota, increase the abundance of SCFA-producing bacteria, and thereby promote PYY secretion (38, 165)