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They are also present in the brain, particularly in areas involved in learning and memory

Long-term effects unknown : While the clinical trials look promising, the long-term safety and efficacy of semaglutide, especially for weight loss, is still being studied

In SURMOUNT 4, all participants received the maximum tolerated dose of tirzepatide for 36 weeks and were then randomized 1:1 to continue tirzepatide or receive placebo until 88 weeks

The procedure is described in more detail elsewhere [17, 18, 22]