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argue that higher concentrations of metformin are necessary in in vitro cell culture protocols because the abundance of growth factors and nutrients, such as glucose, reduces the sensitivity to the inhibitory effects of metformin thus reflecting the importance of glucose and the Warburg effect for cancer cell growth as well as the importance of glycemic control in diabetes (249)

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For all patients, TA was totally effective in preventing AE: the frequency decreased from an average of 2 attacks per month before TA, to 0 attacks per month during TA

Asian Australas J Anim Sci 2005;18:27781