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Managing stress through whatever methods work for you (exercise, meditation, adequate rest, social support) removes a barrier to the medication working optimally

Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor--expressing cells in the nucleus tractus solitarius of ovariectomized rats

Annals of the New York Academy of Sciences , 1112, 4251

If you dont have one of those conditions but your BMI is between 30 and 34.9, you may qualify if you have chronic kidney disease, uncontrolled high blood pressure (hypertension) or heart failure with preserved ejection fraction

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