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Reconstitution Note

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EZH2 represses IGFBP1 (a decidualization marker) by increasing H3K27Me3 at the IGFBP1 promoter, impairing decidualization, while EZH2 knockdown or conditional deletion in mouse ESCs rescues decidualization defects and improves fertility ( Chromatin remodeling factors also play a pivotal role

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