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Bath application of GLP-1 induces a depolarization in most hippocampal neurons and a hyperpolarization in a few neurons ( in vitro electrophysiological recordings further demonstrated that exendin-4 elicits an early fast excitatory response dose-dependently (Hsu et al., 2015, 2018)

Further, in fructose HFD-induced models, ovariectomy has been shown to reverse the reduced susceptibility of female mice to liver damage 92