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Semaglutide works by activating GLP-1 receptors, which stimulates insulin secretion in response to meals, reduces glucagon release, and slows gastric emptying

Interestingly, after a week-long suppression of the gut microbiota with oral broad-spectrum antibiotics cocktail, a rechallenge with oral d 9 -BB showed complete suppression of d 9 -TMAO formation in subjects, confirming gut microbiotadependent conversion of BB into TMAO (Figure 2A, open circles)

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Diabetes & Metabolic Syndrome Clinical Research & Reviews, [online] 16(3), pp.102427102427

PMID: 32310447