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Take home points: Empagliflozin has a large study that shows a small but significant reduction in death and heart failure hospitalizations (NNT for primary outcome = 63 patients for ~3 years) compared to placebo in patients with diabetes and CV disease Empagliflozin can cause urinary and genital infections and ketoacidosis with near normal glucose Because of its mechanism (spilling glucose through the urine), it may develop a role in diabetes mellitus type 1 Refrences: American Diabetes Association: Standards of medical care in diabetes - 2016

Conversely, a recent report by Virmani et al

GI strategies: smaller, more frequent meals

pg 183-193