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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

Regular physical activity also helps maintain bowel regularity

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In addition, measurement tools differ in sensitivity, reproducibility, and control of state-related confounding, further complicating comparison across studies

Biologic activity of mitochondrial metabolites on aging and age-related hearing loss