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Chem Soc Rev 41(7):27402779 Dreinhfer K, Stucki G, Ewert T, Huber E, Ebenbichler G, Gutenbrunner C et al (2004) ICF Core Sets for osteoarthritis

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To alter the binding pocket of Peredox to favour NADP binding, we introduced mutations known to switch the specificity of the Rex domain from favouring NADH binding to favouring NADPH 15 and generated combinatorial mutants thereof