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Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)

and reported that in CD patients in sustained steroid-free remission undergoing combination therapy with infliximab and an immunomodulating drug, the withdrawal of infliximab should only be considered after a careful assessment of the risks and benefits for the individual patient, whereas the withdrawal of the immunomodulatory drug could generally represent the preferred strategy [93]

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