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Canonical morphogens (e.g., Wnt/-catenin, Shh, BMP, Notch) integrate with mechanical inputs and ECM stiffness to drive fate specification, while angiogenic remodeling enhances oxygen and nutrient delivery to support proliferative bursts

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15 e-GST activity e-GST activity was determined with a spectrophotometric assay at 340 nm (37 C)