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There are no clear published guidelines for management of skin pigmentation despite some clinical trials of shorter duration and small sample sizes

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Intervention studies employing dopaminergic neuron-targeted PGC-1 overexpression via adeno-associated viral vectors reveal enhanced redox homeostasis in striatal neurons and marked attenuation of programmed dopaminergic cell death, establishing this transcriptional coactivators neuroprotective capacity in PD pathophysiology (Wang et al., 2019c)

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The UroLift System treatment has demonstrated a significant improvement in quality of life for patients that is greater than reported for medications