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And although we have really elegant artificial intelligence models to try to predict the rate of progression and the time that somebody might get close to the point where they might consider kidney replacement therapy, those methods are reasonably good, but any individual patient can have a very stuttering sort of course during progressive kidney disease

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The 1st glutathione-interaction site should be frequently (although transiently) occupied by GSH at millimolar concentrations, whereas diverse non-glutathione disulfide substrates are far less abundant in vivo and should encounter the active site less frequently

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