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Oral semaglutide at $289/mo (or $249/mo on the 6-month plan) provides an alternative if injection side effects persist, though oral formulations are absorbed differently and may trigger different digestive responses in some patients

This work has significant implications for understanding muscle preservation during fat loss

The dual agonism is why tirzepatide produces greater weight loss than semaglutide, a selective GLP-1 agonist, as seen in trials comparing the two agents

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Glucose Control and Insulin Sensitivity Both drugs improve glycemic control , but Tirzepatide shows superior HbA1c reduction in patients with type 2 diabetes