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A large 2023 study including people without diabetes who were using GLP-1 agonists for weight loss found that this class of medications may increase the risk of gastrointestinal conditions, such as gastroparesis

Schmidt PHS, et al

Published Tuesday in The New England Journal of Medicine, the Phase 3 TRANSCEND trial confirms that setmelanotide (IMCIVREE) produced a placebo-adjusted BMI reduction of nearly 20 percentage points over 52 weeks, establishing peer-reviewed evidence for the first and only FDA-approved drug targeting acquired hypothalamic obesity

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Stillbirth rates are also slightly elevated at 0.6-1.0% compared to 0.4-0.6% in women without these conditions