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The occurrence of a single subject with evidence of overt hemolysis associated with an amustaline/GSH antibody would require a clinical hold with evaluation and DSMB and FDA approval to continue enrolment

Express 8 , 34493457 (2017)

SL could inhibit oxidative stress, prevent the activation of HSCs and activate immune cells (Kupffer cells), thus reducing oxidative damage, in the presence of elevated liver enzymes

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Baser H, Can U, Baser S, Yerlikaya FH, Aslan U, Hidayetoglu BT (2015) Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis