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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)
A broad inflammatory response and severe myelin distortion resulting from such anomalies might result in an immunological response in the CNS analogous to the pathophysiological circumstances of multiple sclerosis
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According to a study in Experimental Gerontology, The free radical theory of aging proposes that oxidative stress plays a key role in the aging process
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