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These included TCA cycle intermediates such as citrate, cis -aconitate, -ketoglutarate, and various amino acids including glutamate, proline, aspartate, asparagine, and alanine as well as glutathione, pyroglutamate, and ornithine

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Vitalsign changes include mild tachycardia in 24% of patients and small blood pressure reductions

P38 mapk inhibitor sb202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model