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More significantly, we were able to link ACTL6A with NRF2-related antioxidant pathway, and to link NRF2 with ferroptosis

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Notably, heme oxygenase 1 (HO1), which has a dual role in regulating ferroptosis, oxidizes cellular heme to carbon monoxide, ferrous iron, and biliverdin [25]

PLoS ONE 8 , e77284 (2013)