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This may be due to NLY01 not crossing BBB at pharmacological concentration but exendin-4 and DA5-CH could achieve that

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GLP-1R can restore the mitochondrial membrane potential, promote ATP production, and reduce ROS production by activating the cAMP/PKA pathway (Signorile et al., 2022)

However, there is little evidence that they cause congenital abnormalities in the fetuses of women taking them inadvertently around conception

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