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Although clinical trials show encouraging results, challenges such as variability in histological outcomes, limited long-term data, and high costs persist
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For patients planning pregnancy, semaglutide should be discontinued at least 2 months before a planned pregnancy due to the long half-life, while tirzepatide may persist for approximately 1 month
The findings of a large US real-world cohort (n= 18,000) study, published in 2024, show that patients on tirzepatide were significantly more likely to achieve 5 %, 10 % and 15 % weight loss compared with semaglutide (HR 1.76, 2.54, 3.24, respectively), with a 12-month mean weight difference of -6.9% 8
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