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Individuals with genetic single nucleotide polymorphisms (SNPs) resulting in hyperactive IIS may be at special risk for the development of age-related diseases, predominantly when their high intrinsic IIS is superposed by exaggerated IIS of Western diet

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Therefore, a complete cure is rare, and therefore treatment should be aimed at palliation

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Some people use these medications just for the first few days at each new dose level to get through the adjustment period more comfortably