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VAT and ASAT decreased by up to 43.5 percent after 48 weeks

At the time of the study, all patients had been receiving a daily injection of recombinant human growth hormone (Genotropin, Pfizer, or Norditropin, Novo Nordisk) in the evening for at least 6 months

In the situation of substrate surplus, adipose tissue also switches from OXPHOS to Warburg/glycolysis developing hypertrophy (increased adipocyte size), hyperplasia (increased numbers of adipocytes), or both (Choe et al., 2016)

Most of our patients begin noticing early improvements within the first few weeks after starting treatment