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Research suggests that ROS directly stabilize HIF-1 under hypoxic conditions by oxidizing Fe 2+ to Fe 3+ at the active site of prolyl hydroxylase enzymes [42,43,44]

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Dysregulation of lactylation, a key regulatory mechanism in cell metabolism and gene expression, can either impede or promote tumor growth and metastasis

2020 Sep 24;9(10):909

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