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Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)
In fact, corticosteroids may weaken tendon structure over time
These rapid mood fluctuations, particularly the emergence or intensification of depressive and anxious states, can significantly disrupt daily functioning and interactions with others, severely impacting an individual's overall well-being
Methods: Following the PRISMA guidelines, we conducted a comprehensive search on electronic databases to obtain relevant studies until 29/12/2024