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No answer can be given to the above open questions because PAC efficacy/adverse effects, unlike most of the drugs repositioned for COVID-19 therapy, have not yet been evaluated in controlled clinical trials or analyzed through retrospective analyses

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Diagnostic and pharmacological potency of creatine in post-viral fatigue syndrome

However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein