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Lipid-poor apoA-I stimulates efflux via ABCA1, whereas lipidated apoA-I or mature HDL are the main drivers of efflux via ABCA1, ABCG1, SR-BI, and aqueous diffusion (Figure 2) (61,69-71)

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This is not in dispute

It rejected emideltide, a peptide for sleep disorders, but the FDA retains final say