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A Type II variation application has been submitted to the European Medicines Agency (EMA) seeking the approval of teclistamab (Tecvayli) monotherapy for the treatment of adult patients with relapsed/refractory multiple myeloma who have received at least 1 prior line of therapy.1 The application is supported by data from the phase 3 MajesTEC-9 trial (NCT05572515), which showed that teclistamab reduced the risk of disease progression or death by 71% compared with standard-of-care (SOC) therapy (HR, 0.29