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Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or dehydration risk, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, and any personal or family history of medullary thyroid carcinoma or MEN2

There are some important practical things to understand before it can be adopted more broadly

Age alone doesnt necessitate reduction in tirzepatide dosing for weight loss in units, though older adults may require closer monitoring during dose escalation

They provide cardiovascular and renal benefits aligned with NICE guidance (NG28) for comprehensive diabetes management