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However, in diabetic wounds, the transition from M1 to M2 is disrupted, leading to the accumulation of M1 macrophages, which produce ROS and sustain long-term inflammation

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Statistics and reproducibility Statistical significance was determined using independent t -test for immunohistochemical and western blot analyses, and one-way analysis of variance for cell cycle and apoptosis detection by GraphPad Prism 7.0 software (GraphPad, Inc., La Jolla, CA, USA)