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(92) conducted a 16-week randomized, double-blind, controlled trial with 196 patients, finding that omega-3 PUFAs significantly reduced the total number of migraine attacks compared to placebo, though a strong placebo effect was observed, and the study did not confirm earlier findings from smaller studies

Atherosclerosis 117:179188 Toborek M, Lee YW, Pu H, Malecki A, Flora G, Garrido R, Hennig B, Bauer HC, Nath A (2003) HIV-tat protein induces oxidative and inflammatory pathways in brain endothelium

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