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The field of weight management is moving toward a deeper understanding of how hormones influence hunger, energy balance, metabolism, and fat storage rather than focusing only on calorie restriction

- Then, in ATTAIN-MAINTAIN, those same individuals were randomized for another 52 weeks to once daily orforglipron vs placebo, on top of lifestyle support

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It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

Weight loss medications should only be used under the supervision of a qualified healthcare provider