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Animal studies of GIP receptor agonism produce conflicting results, including both weight gain and weight loss depending on the model

It will be important to determine to what extent these effects of ERG, as a representative AR-interacting transcription factor, can be extrapolated to other members of the AR protein interactome and how individual interactors impact ARs allostery

Treatment combines strength training, aerobic exercise, dietary changes (especially reducing alcohol and refined sugars), sleep restoration, and (when appropriate) hormone therapy or anti-obesity medications

But it takes the sheer action to kind of activate the molecule