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Merrifield conceived of SPPS in 1959 and took four years to demonstrate the synthesis of a simple tetrapeptide, in a sole-authored Journal of the American Chemical Society (JACS) paper [20] that became among the journals most-ever cited

Unlike insulin or other non discretionary drugs, there is a wide gap between the eligible population and the number of people actually on therapy

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[10] Rare cases of anaphylactoid reactions have been reported following the first dose of oral ketoconazole and during post-marketing use of the 2% shampoo