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Both of these compounds are produced in small amounts in our body and obtained from multiple dietary sources

Patients frequently report memory loss, difficulty concentrating, headaches, and mood disturbances such as anxiety or depression

Graphs were generated with GraphPad Prism version 9.5.0 for MacOS

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The analysis of different isoforms of cytochrome P450 (Cyp2E1, Cyp3A1 and Cyp4A10), involved in bioactivation of APAP into NAPQI, revealed a significant higher expression in transgenic mice challenged with APAP compared to control ones (Fig