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A 2025 study using GHRP-2 stimulation testing in 28 patients with pituitary adenomas established a mean peak GH response of 25.1 ng/mL in subjects with preserved somatotroph function, providing normative benchmark data for hypothalamic-pituitary organoid transplantation research (PMID 40277822

*Correspondence: Giovanna Mantovani, [email protected] Specialty section: This article was submitted to Systems and Translational Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Gopal Grandhige, a board-certified general surgeon specializing in cosmetic surgery, brings extensive surgical expertise to hormone optimization therapy

This timing supports the bodys natural growth hormone release cycle, which peaks during deep sleep stages