Mechanistically, GLP-1 receptor agonists may exert vascular protective effects by suppressing inflammation, limiting oxidative stress, and modulating key enzymes involved in extracellular matrix remodeling ( Matrix metalloproteinases, particularly MMP-9, together with their endogenous inhibitors (TIMPs), play central roles in extracellular matrix turnover and structural vascular remodeling ( The reduction in CRP, a recognized marker of aortic stiffness, medial degeneration, and systemic inflammation, further supports the anti-inflammatory profile associated with GLP-1RA therapy
Microbiota depletion in HFD-fed mice elevates plasma GLP-1 levels and attenuates hypothalamic inflammation, actions that require the astrocyte GLP-1R (49)
Other clues are enlarged lymph nodes and/or symptoms related to other organs
Juan Franco, first author of one of the reviews and researcher at Heinrich Heine University Dsseldorf, Germany, affiliated with the Iberoamerican Cochrane Network
GLP-1s are not weight loss drugs. They are the closest thing we have to a multi-organ longevity drug, and we are mostly using them to make better before-and-after photos