Diabetes Care (2021) 44(Suppl 1):S11124
AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)
While app usage metrics served as useful proxies for engagement, they may not fully capture the quality or intent of user interactions
After all, who wants to be told they are not "fat enough"
Therapeutic approaches aimed at enhancing these functions, for instance, by boosting efferocytosis, may accelerate NETs clearance [281, 282]