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When it does happen, it's usually because of rapid weight loss, not getting enough nutrients, or stress on the body, rather than the drug itself

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The physiological effects of GLP-1 include stimulating insulin secretion in a glucose-dependent manner (Holz Iv et al 1993), inhibiting glucagon release, and slowing gastric emptying

[7] [13] It has a half-life of approximately five days that supports weekly dosing