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In contrast, its use in specific clinical contextssuch as circadian rhythm sleep disorders, neurodegenerative diseases, or metabolic dysregulationis addressed as an adjunctive therapeutic approach, where evidence remains heterogeneous and often limited to small-scale or short-term studies

Based on expert recommendations, estimated energy requirements for individuals using a GLP-1RA are 1,2001,500 kcal/d for females and 1,5001,800 kcal/d for males (7)

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression

Dimebon has recently been reported to have failed in clinical trials for Huntingtons and Alzheimers diseases [49,50,51]

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